The Yu Lab
UMass Chan Medical School
Department of Biochemistry and Molecular Biotechnology
Unraveling the Proteotype: Insights into Health and Disease through Systems Proteomics and Chemical Biology
The proteotype, encompassing the complete interactive ensemble of proteins expressed by an organism or in a single cell, is the crucial bridge connecting genetic information (genotype) to observable characteristics (phenotype). However, our understanding of the proteotype remains significantly limited, due to the extreme complexity and a lack of tools. Pioneering technology innovation in proteomics, our multidisciplinary team is dedicated to unraveling the complexities of the proteotype in both health and disease. We delve into the dynamic world of proteins to decipher their roles in cellular signaling and aim to systematically elucidate the molecular mechanisms underlying various physiological and pathological processes (e.g., aging, cancer). Our mission extends beyond mere exploration, as we strive to leverage these insights to catalyze advancements in drug discovery.
Research Highlights
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input
Cell Chemical Biology, 2023
Deep Proteomic Compound Profiling with the Orbitrap Ascend Tribrid Mass Spectrometer Using Tandem Mass Tags and Real-Time Search
Analytical Chemistry, 2023
Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Nature Communications, 2023
Adapting an Isobaric Tag-Labeled Yeast Peptide Standard to Develop Targeted Proteomics Assays
Journal of Proteome Research, 2023
Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics
Nature Communications, 2022
Sample multiplexing for targeted pathway proteomics in aging mice
Proceedings of the National Academy of Sciences of the United States of America, 2020
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