The Yu Lab


UMass Chan Medical School

Department of Biochemistry and Molecular Biotechnology

Unraveling the Proteotype: Insights into Health and Disease through Systems Proteomics and Chemical Biology


The proteotype, encompassing the complete interactive ensemble of proteins expressed by an organism or in a single cell, is the crucial bridge connecting genetic information (genotype) to observable characteristics (phenotype). However, our understanding of the proteotype remains significantly limited, due to the extreme complexity and a lack of tools. Pioneering technology innovation in proteomics, our multidisciplinary team is dedicated to unraveling the complexities of the proteotype in both health and disease. We delve into the dynamic world of proteins to decipher their roles in cellular signaling and aim to systematically elucidate the molecular mechanisms underlying various physiological and pathological processes (e.g., aging, cancer). Our mission extends beyond mere exploration, as we strive to leverage these insights to catalyze advancements in drug discovery. 

Research Highlights

Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input

Cell Chemical Biology, 2023

Deep Proteomic Compound Profiling with the Orbitrap Ascend Tribrid Mass Spectrometer Using Tandem Mass Tags and Real-Time Search

Analytical Chemistry, 2023


Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression

Nature Communications, 2023

Adapting an Isobaric Tag-Labeled Yeast Peptide Standard to Develop Targeted Proteomics Assays

Journal of Proteome Research, 2023

Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics

Nature Communications, 2022

Sample multiplexing for targeted pathway proteomics in aging mice

Proceedings of the National Academy of Sciences of the United States of America, 2020

 © 2024 Yu Research Group