The Yu Lab

Unraveling the Proteotype: Insights into Health and Disease through Systems Proteomics and Chemical Biology

The proteotype, encompassing the complete interactive ensemble of proteins expressed by an organism or in a single cell, is the crucial bridge connecting genetic information (genotype) to observable characteristics (phenotype). However, our understanding of the proteotype remains significantly limited, due to the extreme complexity and a lack of tools. Pioneering technology innovation in proteomics, our multidisciplinary team is dedicated to unraveling the complexities of the proteotype in both health and disease. We delve into the dynamic world of proteins to decipher their roles in cellular signaling and aim to systematically elucidate the molecular mechanisms underlying various physiological and pathological processes (e.g., aging, cancer). Our mission extends beyond mere exploration, as we strive to leverage these insights to catalyze advancements in drug discovery. 

Research Highlights

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